bs-82734C
[Life Science]
SJ6986
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
Description:
CAS Number: 2765625-93-0<br></br>Chemical Name: N-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide<br></br>Molecular weight: 433.34<br></br>Formula: C20H14F3N3O5<br></br>Solubility: DMSO (>40 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC , NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.