bs-82728C
[Life Science]
Iberdomide
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Iberdomide is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 of CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
Description:
CAS Number: 1323403-33-3<br></br>Chemical Name: (S)-3-(4-((4-(Morpholinometnyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione<br></br>Molecular weight: 449.51<br></br>Formula: C25H27N3O5<br></br>Solubility: DMSO (50 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC , NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.