bs-82720C
[Life Science]
SI-2
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3
Description:
CAS Number: 380537-35-9<br></br>Chemical Name: 1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine<br></br>Molecular weight: 265.31<br></br>Formula: C15H15N5<br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: Pale orange solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.