bs-82713C

DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP) IC50=1.54 M and >10 M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1

Description:

CAS Number: 2161305-12-8 Chemical Name: (Z)-3-((3-nitrophenyl)amino)-1-phenylprop-2-en-1-one Molecular weight: 268.27 Formula: C15H12N2O3 Solubility: DMSO (50 mg/ml) Ethanol (10 mg/ml) Organic solvents such as chloroform (50 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC NMR (Conforms)