DATASHEET
Formulation
Orange solid
Storage:
-20°C
Product Information:
A selective PARP-2 inhibitor (IC50=0.3 µM and ~ 27-fold selective against PARP-1).1,2 Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3 Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4
Description:
CAS Number: 1048371-03-4<br></br>Chemical Name: 5-(2-Oxo-3-phenylethoxy)-1(2H)-isoquinolinone<br></br>Molecular weight: 279.29<br></br>Formula: C17H13NO3 <br></br>Solubility: DMSO (40 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by TLC, NMR (Conforms)