DATASHEET
Formulation
Pale yellow solid
Storage:
-20°C
Product Information:
A novel, orally active, small molecule human thrombopoietin receptor (TPO-R) agonist, EC50=0.27 M.1,2 Maintains human hematopoietic stem and progenitor cells under inflammatory conditions.3 Promotes DNA repair in human hematopoietic stem and progenitor cells.4 Acts as a powerful chelator of cellular and extracellular iron(III).5 Stimulates hematopoietic stem cells via a TPO-R-independent mechanism involving iron chelation.6
Description:
CAS Number: 496775-61-2<br></br>Chemical Name: 3’-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2’-hydroxy-[1,1’-biphenyl]-3-carboxylic acid<br></br>Molecular weight: 442.47<br></br>Formula: C25H22N4O4 <br></br>Solubility: DMSO (55 mg/ml) Ethanol (14 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC NMR (Conforms)