bs-82707C
[Life Science]
Tafamidis
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
Description:
CAS Number: 594839-88-0<br></br>Chemical Name: 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic <br></br>Molecular weight: 308.12<br></br>Formula: C14H7Cl2NO3<br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.