bs-82701C
[Life Science]
NLRP3i
DATASHEET
Formulation Yellow solid
Storage: RT
Product Information:
NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1 and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2
Description:
CAS Number: 16673-34-0<br></br>Chemical Name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide <br></br>Molecular weight: 368.84<br></br>Formula: C16H17ClN2O4S<br></br>Solubility: DMSO (45 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 20 mg, 100 mg20 mg, 100 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.