bs-82696C
[Life Science]
IMR-1
DATASHEET
Formulation Viscous oil
Storage: -20°C
Product Information:
Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
Description:
CAS Number: 310456-65-6<br></br>Chemical Name: 2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester<br></br>Molecular weight: 353.41<br></br>Formula: C15H15NO5S2 <br></br>Solubility: DMSO (45 mg/ml) Ethanol (9 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.