bs-82691C
[Life Science]
Verrucarin A
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
Description:
CAS Number: 3148-09-2<br></br>Chemical Name: <br></br>Molecular weight: 502.56<br></br>Formula: C27H34O9<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by HPLC, NMR (conforms)
Size: 1 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.