bs-82687C
[Life Science]
AA43279
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 µM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1
Description:
CAS Number: 354812-16-1<br></br>Chemical Name: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide<br></br>Molecular weight: 248.30<br></br>Formula: C12H12N2O2S<br></br>Solubility: DMSO (35 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 97% by TLC NMr (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.