bs-82684C
[Life Science]
Streptonigrin
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
Description:
CAS Number: 3930-19-6<br></br>Chemical Name: Fermentation product from Streptomyces flocculus<br></br>Molecular weight: 506.47<br></br>Formula: C25H22N4O8<br></br>Solubility: DMSO<br></br>Physical Properties: Black solid<br></br>Purity: >95% HPLC, NMR (Conforms)
Size: 1 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.