bs-82681C
[Life Science]
Piericidin A
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
A potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I).1 Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme.2 It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology.3-5 Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).6
Description:
CAS Number: 2738-64-9<br></br>Chemical Name: 2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol<br></br>Molecular weight: 415.57<br></br>Formula: C25H37NO4<br></br>Solubility: DMSO (25 mg/ml) Ethanol (20 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 94% by HPLC NMR (Conforms)
Size: 1 mg,200 ug200 ug
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.