bs-82671C
[Life Science]
RITA
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 (human ortholog of MDM2, Mouse Double-Minute clone 2), and targeting it for proteasomal degradation.1 It also weakly (computed Kd = 22 µM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6
Description:
CAS Number: 213261-59-7<br></br>Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol<br></br>Molecular weight: 292.37<br></br>Formula: C14H12O3S2<br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC NMr (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.