bs-82666C
[Life Science]
Koningic acid
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 μM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5
Description:
CAS Number: 74310-84-2<br></br>Chemical Name: (2’S,5aS,6R,9aS)-1,5a,6,7,8,9a-Hexahydro-6-(1-methylethyl)-1-oxo-spiro[2-benzoxepin-9(3H)2’-oxirane]-4-carboxylic acid<br></br>Molecular weight: 280.32<br></br>Formula: C15H20O5<br></br>Solubility: Water (1 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 95% by HPLC, NMR (Conforms)
Size: 1 mg, 2.5 mg 2.5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.