bs-82643C
[Life Science]
Z-Phe-Tyr-CHO
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
A potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2
Description:
CAS Number: 167498-29-5<br></br>Chemical Name: <br></br>Molecular weight: 446.50<br></br>Formula: C26H26N2O5<br></br>Solubility: DMSO (30 mg/ml) Ethanol (50 mg/ml)<br></br>Physical Properties: Off-white to pale yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.