bs-82642C
[Life Science]
Tolcapone
DATASHEET
Formulation Light yellow solid
Storage: -20°C
Product Information:
Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable
Description:
CAS Number: 134308-13-7<br></br>Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone<br></br>Molecular weight: 273.24<br></br>Formula: C14H11NO5<br></br>Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.