bs-82637C
[Life Science]
Nilvadipine
DATASHEET
Formulation Pale yellow to off-white solid
Storage: -20°C
Product Information:
A novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model.1 Clinically useful antihypertensive agent.2 Has been shown to prevent cognitive decline in some clinical trials.3 Produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.4
Description:
CAS Number: 75530-68-6<br></br>Chemical Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester<br></br>Molecular weight: 385.38<br></br>Formula: C19H19N3O6 <br></br>Solubility: DMSO (25 mg/ml) Ethanol (15 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 50 mg, 250 mg50 mg, 250 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.