bs-82636C
[Life Science]
Homoharringtonine
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
Description:
CAS Number: 26833-87-4<br></br>Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate<br></br>Molecular weight: 545.63<br></br>Formula: C29H39NO9<br></br>Solubility: DMSO (75 mg/ml)<br></br>Physical Properties: Pale yellow to off-white solid<br></br>Purity: 95% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.