DATASHEET
Formulation
White to off-white solid
Storage:
-20°C
Product Information:
Cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2 Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3 Blocks AIF-mediated necroptosis.4 Cell permeable.
Description:
CAS Number: 110044-82-1<br></br>Chemical Name: Ac-Leu-Leu-Nle-CHO<br></br>Molecular weight: 383.53<br></br>Formula: C20H37N3O4<br></br>Solubility: DMSO (10 mg/ml) Ethanol (5 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)