DATASHEET
Formulation
White solid
Storage:
-20°C
Product Information:
Potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture.1 Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.2-4
Description:
CAS Number: 253863-19-3<br></br>Chemical Name: (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione<br></br>Molecular weight: 362.38<br></br>Formula: C19H22O7<br></br>Solubility: DMSO (9 mg/ml) Ethanol (3 mg/ml) <br></br>Physical Properties: White to off-white solid<br></br>Purity: >98% by HPLC NMR (Conforms)