bs-82630C
[Life Science]
Torin 1
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
Potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).2 Induces autophagy.3 Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.4 Downregulates NGF expression in RSC96 cells.5
Description:
CAS Number: 1222998-36-8<br></br>Chemical Name: 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one<br></br>Molecular weight: 607.62<br></br>Formula: C35H28F3N5O2<br></br>Solubility: DMSO (8 mg/ml)<br></br>Physical Properties: White or off-white solid<br></br>Purity: 98% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.