bs-82628C
[Life Science]
MDL-28170
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.4
Description:
CAS Number: 88191-84-8<br></br>Chemical Name: N-Benzyloxycarbonylvalylphenylalaninal<br></br>Molecular weight: 382.45<br></br>Formula: C22H26N2O4<br></br>Solubility: DMSO (75 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.