bs-82626C
[Life Science]
CX-5461
DATASHEET
Formulation White solid
Storage: RT
Product Information:
CX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5
Description:
CAS Number: 1138549-36-6<br></br>Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo [3,2-a][1,8]naphthyridine-6-carboxamide<br></br>Molecular weight: 513.62<br></br>Formula: C27H27N7O2S<br></br>Solubility: DMSO (10 mg/ml with warming)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.