bs-82624C
[Life Science]
MCC-950
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
MCC-950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.
Description:
CAS Number: 210826-40-7<br></br>Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt<br></br>Molecular weight: 426.46<br></br>Formula: C20H23N2O5S Na<br></br>Solubility: DMSO (40 mg/ml) Water (30 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.