bs-82619C
[Life Science]
Embelin
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.
Description:
CAS Number: 550-24-3<br></br>Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione<br></br>Molecular weight: 294.39<br></br>Formula: C17H26O4 <br></br>Solubility: DMSO (30 mg/ml) Ethanol (3 mg/ml)<br></br>Physical Properties: Dark orange solid<br></br>Purity: 98% by HPLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.