bs-82616C
[Life Science]
Leelamine HCl
DATASHEET
Formulation White lyophilized solid
Storage: -20°C
Product Information:
A lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6
Description:
CAS Number: 16496-99-4<br></br>Chemical Name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride <br></br>Molecular weight: 321.93<br></br>Formula: C20H31N ∙ HCl <br></br>Solubility: DMSO (40 mg/ml) Water (9 mg/ml)<br></br>Physical Properties: Off-white or beige solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.