bs-82612C
[Life Science]
PLX-4032
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively.1 Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response.2 Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo.3 Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.4
Description:
CAS Number: 918504-65-1<br></br>Chemical Name: N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide<br></br>Molecular weight: 489.92<br></br>Formula: C23H18ClF2N3O3S <br></br>Solubility: DMSO (100 mg/ml)<br></br>Physical Properties: White or off-white solid<br></br>Purity: 99% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.