bs-82607C

DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

Potent and selective inhibitor of Src family kinases, IC50=4-10 nM for Src, c-Yes, Fyn, Lyn, Blk, Fgr and Lck.1 Demonstrates potent antimigratory, anti-invasive and antiproliferative activity and inhibits metastasis in a mouse model of bladder cancer.2 Inhibits MERS- CoV at early stages of the viral life cycle at mM concentrations.3,4 Rescues memory performance and reduces phospho-Tau accumulation in traumatic tauopathy.5 Rescues memory deficits and synaptic depletion in an Alzheimer’s mouse model.6

Description:

CAS Number: 379231-04-6 Chemical Name: N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine Molecular weight: 542.03 Formula: C27H32ClN5O5 Solubility: DMSO (50 mg/ml) and ethanol (54 mg/mL with warming) Physical Properties: White solid Purity: >98% HPLC, NMR (Conforms)

Size: 5 mg, 25 mg5 mg, 25 mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.