bs-82596C
[Life Science]
SB-225002
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe.2 Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages.4 Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation.5
Description:
CAS Number: 182498-32-4<br></br>Chemical Name: N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea<br></br>Molecular weight: 352.14<br></br>Formula: C13H10BrN3O4<br></br>Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.