bs-82586C
[Life Science]
Riluzole
DATASHEET
Formulation White solid
Storage: RT
Product Information:
Riluzole is a clinically useful drug for the treatment of amyotrophic lateral sclerosis (ALS).1 Riluzole inhibits glutamate release via inactivation of voltage-dependent ion channels, effects expression and signal transduction of glutamate receptors, and facilitates glutamate uptake.2,3,4 It has also been investigated as a treatment for depression and anxiety.5 Riluzole induced apoptosis in mGluR1-expressing melanoma cells6, inhibited cell proliferation in a U87MG glioblastoma model via blockage of glutamate release7, and inhibited the growth of brain tumor stem-like cells via downregulation of GLUT3.
Description:
CAS Number: 1744-22-5<br></br>Chemical Name: 2-Amino-6-(trifluoromethoxy)benzothiazole<br></br>Molecular weight: 234.20<br></br>Formula: C8H5F3N2OS<br></br>Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 20 mg, 100 mg20 mg, 100 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.