bs-82555C
[Life Science]
Probucol
DATASHEET
Formulation Off-white solid
Storage: RT
Product Information:
Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
Description:
CAS Number: 23288-49-5<br></br>Chemical Name: 4,4’-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol<br></br>Molecular weight: 516.84<br></br>Formula: C31H48O2S2<br></br>Solubility: DMSO (100 mg/ml) Ethanol (50 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by HPLC / TLC NMR (Conforms)
Size: 1 g, 10 g1 g, 10 g
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.