bs-82553C
[Life Science]
Swainsonine
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
A naturally occurring alkaloidal toxin found in locoweed. Inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II (IC50 = 0.2 μM).1 Inhibits growth and potentiates the cytotoxic effect of taxol in hepatocellular carcinoma in vivo.2 Induces apoptosis in a variety of cell types including cerebral cortical neurons.3 Impairs adult neurogenesis and spatial learning and memory.4 Abrogation of complex glycosylation by swainsonine results in strain-and cell-specific inhibition of prion replication.5 Induces lysosomal storage disease in farm animals.6
Description:
CAS Number: 72741-87-8<br></br>Chemical Name:
(1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol
<br></br>Molecular weight: 173.21<br></br>Formula: C8H15NO3<br></br>Solubility: DMSO (10 mg/ml) Ethanol (10 mg/ml) Water (8 mg/ml)<br></br>Physical Properties: White or off-white solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.