bs-82478C
[Life Science]
ß-Lapachone
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
Description:
CAS Number: 4707-32-8<br></br>Chemical Name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione<br></br>Molecular weight: 242.27<br></br>Formula: C15H14O3<br></br>Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.