bs-82450C
[Life Science]
L-Cycloserine
DATASHEET
Formulation Light yellow solid
Storage: -20°C
Product Information:
L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
Description:
CAS Number: 339-72-0<br></br>Chemical Name: (S)-4-Amino-3-isoxaolidinone<br></br>Molecular weight: 102.09<br></br>Formula: C3H6N2O2<br></br>Solubility: DMSO (20 mg/ml) with warming, Water (25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 20 mg, 100 mg20 mg, 100 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.