bs-82425C

DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

Novel Class I phosphatidylinositol 3-kinase (PI3K) inhibitor. ZSTK474 is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, it inhibits PI3Kδ most potently, with a Ki of 1.8 nM, while inhibiting the α, β and γ isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively)1. Displays potent antitumor activity against human cancer xenografts (A549, PC-3 and WiDr) when administered to mice2. It displays potent anti-inflammatory activity via modulation of human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis3. Ameliorates the progression of adjuvant-induced arthritis in a rat model4.

Description:

CAS Number: 475110-96-4 Chemical Name: 2-(2-Difluoromethylbenzoimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine Molecular weight: 417.41 Formula: C19H21F2N7O2 Solubility: DMSO (20 mg/ml) Ethanol (2.5 mg/ml) Physical Properties: White or off-white solid Purity: 99% by HPLC NMR (Conforms)