bs-82413C

DATASHEET

Formulation Waxy lyophilized solid

Storage: -20°C

Product Information:

Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3

Description:

CAS Number: 136572-09-3 Chemical Name: (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride Molecular weight: 586.69 ∙ 36.46 ∙ 54.05 Formula: C33H38N4O6 ∙ HCl ∙ 3H20 Solubility: DMSO (50 mg/ml) Ethanol (4 mg/ml) Water (4 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)

Size: 50 mg, 250 mg50 mg, 250 mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.