bs-82404C
[Life Science]
Dovitinib
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
Potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
Description:
CAS Number: 405169-16-6<br></br>Chemical Name: 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one<br></br>Molecular weight: 392.43<br></br>Formula: C21H21FN6O<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: Yellow-green solid<br></br>Purity: 99% by TLC, 99% by HPLC
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.