bs-82400C
[Life Science]
Bosutinib
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5
Description:
CAS Number: 380843-75-4<br></br>Chemical Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile<br></br>Molecular weight: 530.45<br></br>Formula: C26H29Cl2N5O3<br></br>Solubility: DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.