bs-82398C
[Life Science]
Axitinib
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3 Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.4
Description:
CAS Number: 319460-85-0<br></br>Chemical Name: N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide<br></br>Molecular weight: 386.47<br></br>Formula: C22H18N4OS<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 99% by HPLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.