bs-82378C
[Life Science]
Gliotoxin
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
A fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B cells.1 Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. It inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells.5
Description:
CAS Number: 67-99-2<br></br>Chemical Name: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
[1,2-a]indole-1,4-dione; <br></br>Molecular weight: 326.39<br></br>Formula: C13H14N2O4S2<br></br>Solubility: DMSO (15 mg/ml)<br></br>Physical Properties: White lyophilized solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.