bs-82366C
[Life Science]
DRB
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
Description:
CAS Number: 53-85-0<br></br>Chemical Name: 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole<br></br>Molecular weight: 319.14<br></br>Formula: C12H12Cl2N2O4 <br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.