bs-82365C
[Life Science]
Manidipine dihydrochloride
DATASHEET
Formulation White solid
Storage: RT
Product Information:
Manidipine is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature. Manidipine has recently been found to be an inhibitor (IC50 = 4.8 µM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 µM) via inhibition of the Immediate-Early 2 (IE2) protein.4
Description:
CAS Number: 89226-75-5<br></br>Chemical Name: 5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride<br></br>Molecular weight: 683.63<br></br>Formula: C35H38N4O6·2HCl<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (conforms)
Size: 20 mg, 100 mg20 mg, 100 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.