bs-82351C
[Life Science]
ST-034307
DATASHEET
Formulation Yellow solid
Storage: RT
Product Information:
A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1
Description:
CAS Number: 133406-29-8<br></br>Chemical Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one<br></br>Molecular weight: 297.95<br></br>Formula: C10H4Cl4O2 <br></br>Solubility: DMSO (30 mg/ml) Ethanol (6 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.