bs-82350C
[Life Science]
JIB-04
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3
Description:
CAS Number: 199596-05-9<br></br>Chemical Name: (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine<br></br>Molecular weight: 308.76<br></br>Formula: C17H13ClN4<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.