bs-82338C
[Life Science]
AS-8351
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1
Description:
CAS Number: 796-42-9<br></br>Chemical Name: 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone<br></br>Molecular weight: 291.3<br></br>Formula: C17H13N3O2<br></br>Solubility: DMSO (45 mg/ml) DMF (30 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.