bs-82331C
[Life Science]
JQ1 (+)
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Potent BET bromodomain inhibitor and is the active isomer. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively (data for + isomer).1 Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.1 Induces squamous differentiation in NMC cell lines and inhibits tumor growth in NMC xenografts.2 Displays reversible contraceptive effects in male mice.3 Blocks inflammation and bone loss in periodontitis.4 Reverses CAR T cell extinction.5
Description:
CAS Number: 1268524-70-4<br></br>Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester<br></br>Molecular weight: 456.99<br></br>Formula: C23H25ClN4O2S<br></br>Solubility: DMSO (up to 60 mg/ml) or in Ethanol (up to 46 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR conforms
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.