bs-82319C
[Life Science]
UNC-2170 HCl
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
Description:
CAS Number: 1648707-58-7<br></br>Chemical Name: 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride<br></br>Molecular weight: 349.69<br></br>Formula: C14H21BrN2O HCl <br></br>Solubility: DMSO (40 mg/ml) Water (50 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.