bs-82317C
[Life Science]
ML241
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3
Description:
CAS Number: 1346528-06-0<br></br>Chemical Name: N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine<br></br>Molecular weight: 372.46<br></br>Formula: C23H24N4O <br></br>Solubility: DMSO (50 mg/ml) Ethanol (14 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by HPLC NMR (conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.