bs-82315C
[Life Science]
UCF-101
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
UCF-101 is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM).1 Mitigates streptozotocin-induced cardiomyocyte dysfunction.2 Protects against cerebral oxidative injury and cognitive impairment in a rat model.3 Cell permeable.
Description:
CAS Number: 313649-08-0<br></br>Chemical Name: Dihydro-5[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione<br></br>Molecular weight: 495.51<br></br>Formula: C27H17N3O5S<br></br>Solubility: DMSO (30 mg/ml with warming) DMF (25 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.